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  • Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.

    Cell reports

    Authors: Manuel Hayn, Maximilian Hirschenberger, Lennart Koepke, Rayhane Nchioua, Jan Hendrik Straub, Susanne Klute, Victoria Hunszinger, Fabian Zech, Caterina Prelli Bozzo, Wasim Aftab, Maria Hønholt Christensen, Carina Conzelmann, Janis Alexander Müller, Smitha Srinivasachar Badarinarayan, Christina Martina Stürzel, Ignasi Forne, Steffen Stenger, Karl-Klaus Conzelmann, Jan Münch, Florian Ingo Schmidt, Daniel Sauter, Axel Imhof, Frank Kirchhoff, Konstantin Maria Johannes Sparrer

  • Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

    Science (New York, N.Y.)

    Authors: Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M Kümmerer, Florian N Gohr, Lea-Marie Jenster, Lisa D J Schiffelers, Yonas M Tesfamariam, Miki Uchima, Jennifer D Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H Christensen, Caroline I Fandrey, Sabine Normann, Jan M P Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A Wilson, Matthias Geyer, Kerstin U Ludwig, B Martin Hällberg, Nicholas C Wu, Florian I Schmidt

  • HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.

    Science (New York, N.Y.)

    Authors: Venkat Giri Magupalli, Roberto Negro, Yuzi Tian, Arthur V Hauenstein, Giuseppe Di Caprio, Wesley Skillern, Qiufang Deng, Pontus Orning, Hasan B Alam, Zoltan Maliga, Humayun Sharif, Jun Jacob Hu, Charles L Evavold, Jonathan C Kagan, Florian I Schmidt, Katherine A Fitzgerald, Tom Kirchhausen, Yongqing Li, Hao Wu

  • Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant.

    Rheumatology (Oxford, England)

    Authors: Troels Herlin, Sofie E Jørgensen, Christian Høst, Patrick S Mitchell, Maria Hønholt Christensen, Mira Laustsen, Dorthe A Larsen, Florian I Schmidt, Mette Christiansen, Trine H Mogensen

  • Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.

    PLoS pathogens

    Authors: Matteo Bosso, Caterina Prelli Bozzo, Dominik Hotter, Meta Volcic, Christina M Stürzel, Annika Rammelt, Yi Ni, Stephan Urban, Miriam Becker, Mario Schelhaas, Sabine Wittmann, Maria H Christensen, Florian I Schmidt, Thomas Gramberg, Konstantin M J Sparrer, Daniel Sauter, Frank Kirchhoff

  • Jack of all trades inhibits inflammation (in sober people).

    Nature immunology

    Authors: Florian I Schmidt, Eicke Latz

  • Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.

    eLife

    Authors: Jan N Hansen, Fabian Kaiser, Christina Klausen, Birthe Stüven, Raymond Chong, Wolfgang Bönigk, David U Mick, Andreas Möglich, Nathalie Jurisch-Yaksi, Florian I Schmidt, Dagmar Wachten

  • From atoms to physiology: what it takes to really understand inflammasomes.

    The Journal of physiology

    Authors: Florian I Schmidt