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featured publications

  • Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.

    Nature communications

    Authors: Ines H Kaltheuner, Kanchan Anand, Jonas Moecking, Robert Düster, Jinhua Wang, Nathanael S Gray, Matthias Geyer

  • Four hypotrichosis families with mutations in the gene LSS presenting with and without neurodevelopmental phenotypes.

    American journal of medical genetics. Part A

    Authors: Nicole Cesarato, Maria Wehner, Mariam Ghughunishvili, Axel Schmidt, Daisy Axt, Holger Thiele, Michael J Lentze, Cristina Has, Matthias Geyer, Fitnat Buket Basmanav, Regina C Betz

  • Global mapping of Salmonella enterica-host protein-protein interactions during infection.

    Cell host & microbe

    Authors: Philipp Walch, Joel Selkrig, Leigh A Knodler, Mandy Rettel, Frank Stein, Keith Fernandez, Cristina Viéitez, Clément M Potel, Karoline Scholzen, Matthias Geyer, Klemens Rottner, Olivia Steele-Mortimer, Mikhail M Savitski, David W Holden, Athanasios Typas

  • Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures.

    Antioxidants (Basel, Switzerland)

    Authors: Constanze Erdmann, Roua Hassoun, Sebastian Schmitt, Carlos Kikuti, Anne Houdusse, Antonina J Mazur, Andreas Mügge, Nazha Hamdani, Matthias Geyer, Kornelia Jaquet, Hans Georg Mannherz

  • Top publication

    LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.

    Nature biotechnology

    Authors: Kerstin U Ludwig, Ricarda M Schmithausen, David Li, Max L Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M Hochfeld, Eva C Beins, Ines H Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Eva-Maria C Moench, Jacob D Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus M Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L Schmid-Burgk

  • Development of Fluorescent and Biotin Probes Targeting NLRP3.

    Frontiers in chemistry

    Authors: Tim Keuler, Karl Gatterdam, Anil Akbal, Marta Lovotti, Michael Marleaux, Matthias Geyer, Eicke Latz, Michael Gütschow

  • Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.

    European journal of medicinal chemistry

    Authors: Baishan Jiang, Jie Jiang, Ines H Kaltheuner, Amanda Balboni Iniguez, Kanchan Anand, Fleur M Ferguson, Scott B Ficarro, Bo Kyung Alex Seong, Ann Katrin Greifenberg, Sofia Dust, Nicholas P Kwiatkowski, Jarrod A Marto, Kimberly Stegmaier, Tinghu Zhang, Matthias Geyer, Nathanael S Gray

  • Discovery and resistance mechanism of a selective CDK12 degrader.

    Nature chemical biology

    Authors: Baishan Jiang, Yang Gao, Jianwei Che, Wenchao Lu, Ines H Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M Riching, Danette L Daniels, Peter K Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S Gray

  • Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling.

    Nature chemical biology

    Authors: Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C Müller, Johannes Zuber, Matthias Geyer, Nicolas H Thomä, Stefan Kubicek, Georg E Winter

  • Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

    Science (New York, N.Y.)

    Authors: Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M Kümmerer, Florian N Gohr, Lea-Marie Jenster, Lisa D J Schiffelers, Yonas M Tesfamariam, Miki Uchima, Jennifer D Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H Christensen, Caroline I Fandrey, Sabine Normann, Jan M P Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A Wilson, Matthias Geyer, Kerstin U Ludwig, B Martin Hällberg, Nicholas C Wu, Florian I Schmidt