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featured publications

  • Top publication

    LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.

    Nature biotechnology

    Authors: Kerstin U Ludwig, Ricarda M Schmithausen, David Li, Max L Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M Hochfeld, Eva C Beins, Ines H Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Eva-Maria C Moench, Jacob D Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus M Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L Schmid-Burgk

  • Development of Fluorescent and Biotin Probes Targeting NLRP3.

    Frontiers in chemistry

    Authors: Tim Keuler, Karl Gatterdam, Anil Akbal, Marta Lovotti, Michael Marleaux, Matthias Geyer, Eicke Latz, Michael Gütschow

  • Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.

    European journal of medicinal chemistry

    Authors: Baishan Jiang, Jie Jiang, Ines H Kaltheuner, Amanda Balboni Iniguez, Kanchan Anand, Fleur M Ferguson, Scott B Ficarro, Bo Kyung Alex Seong, Ann Katrin Greifenberg, Sofia Dust, Nicholas P Kwiatkowski, Jarrod A Marto, Kimberly Stegmaier, Tinghu Zhang, Matthias Geyer, Nathanael S Gray

  • Discovery and resistance mechanism of a selective CDK12 degrader.

    Nature chemical biology

    Authors: Baishan Jiang, Yang Gao, Jianwei Che, Wenchao Lu, Ines H Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M Riching, Danette L Daniels, Peter K Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S Gray

  • Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling.

    Nature chemical biology

    Authors: Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C Müller, Johannes Zuber, Matthias Geyer, Nicolas H Thomä, Stefan Kubicek, Georg E Winter

  • Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

    Science (New York, N.Y.)

    Authors: Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M Kümmerer, Florian N Gohr, Lea-Marie Jenster, Lisa D J Schiffelers, Yonas M Tesfamariam, Miki Uchima, Jennifer D Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H Christensen, Caroline I Fandrey, Sabine Normann, Jan M P Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A Wilson, Matthias Geyer, Kerstin U Ludwig, B Martin Hällberg, Nicholas C Wu, Florian I Schmidt

  • 1,6-Hexanediol, commonly used to dissolve liquid-liquid phase separated condensates, directly impairs kinase and phosphatase activities.

    The Journal of biological chemistry

    Authors: Robert Düster, Ines H Kaltheuner, Maximilian Schmitz, Matthias Geyer

  • NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity.

    The Journal of allergy and clinical immunology

    Authors: Jonas Moecking, Pawat Laohamonthonkul, Katelyn Chalker, Marquitta J White, Cassandra R Harapas, Chien-Hsiung Yu, Sophia Davidson, Katja Hrovat-Schaale, Donglei Hu, Celeste Eng, Scott Huntsman, Dale J Calleja, Jay C Horvat, Phil M Hansbro, Robert J J O'Donoghue, Jenny P Ting, Esteban G Burchard, Matthias Geyer, Motti Gerlic, Seth L Masters

  • Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.

    Genes & development

    Authors: Jenna K Rimel, Zachary C Poss, Benjamin Erickson, Zachary L Maas, Christopher C Ebmeier, Jared L Johnson, Tim-Michael Decker, Tomer M Yaron, Michael J Bradley, Kristin B Hamman, Shanhu Hu, Goran Malojcic, Jason J Marineau, Peter W White, Martine Brault, Limei Tao, Patrick DeRoy, Christian Clavette, Shraddha Nayak, Leah J Damon, Ines H Kaltheuner, Heeyoun Bunch, Lewis C Cantley, Matthias Geyer, Janet Iwasa, Robin D Dowell, David L Bentley, William M Old, Dylan J Taatjes

  • CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8 T Cells.

    Immunity

    Authors: Matthias Braun, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, Luize G Lima, Lizeth G Meza Guzman, Kunlun Li, Rui Li, Nazhifah Salim, Maria Villancanas Jorge, Sunyoung Ham, Gabrielle Kelly, Frank Vari, Ailin Lepletier, Ashwini Raghavendra, Sally Pearson, Jason Madore, Sebastien Jacquelin, Maike Effern, Brodie Quine, Lambros T Koufariotis, Mika Casey, Kyohei Nakamura, Eun Y Seo, Michael Hölzel, Matthias Geyer, Glen Kristiansen, Touraj Taheri, Elizabeth Ahern, Brett G M Hughes, James S Wilmott, Georgina V Long, Richard A Scolyer, Martin D Batstone, Jennifer Landsberg, Dimo Dietrich, Oltin T Pop, Lukas Flatz, William C Dougall, André Veillette, Sandra E Nicholson, Andreas Möller, Robert J Johnston, Ludovic Martinet, Mark J Smyth, Tobias Bald