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featured publications

  • Molecular Urothelial Tumor Cell Subtypes Remain Stable During Metastatic Evolution.

    European urology

    Authors: Alexander Cox, Niklas Klümper, Johannes Stein, Danijel Sikic, Johannes Breyer, Christian Bolenz, Florian Roghmann, Philipp Erben, Ralph M Wirtz, Bernd Wullich, Manuel Ritter, Michael Hölzel, Kristina Schwamborn, Thomas Horn, Jürgen Gschwend, Arndt Hartmann, Wilko Weichert, Franziska Erlmeier, Markus Eckstein

  • Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma.

    Journal for immunotherapy of cancer

    Authors: Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Löffek, Irem Oezel, Roberta Turiello, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Antje Sucker, Eva Hadaschik, Florian Wirsdörfer, Helmut Hanenberg, Niklas Uhlenbrock, Daniel Rauh, Joanna Poźniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Dirk Schadendorf, Jadwiga Jablonska, Michael Hölzel, Iris Helfrich

  • Early C-reactive protein kinetics predicts immunotherapy response in non-small cell lung cancer in the phase III OAK trial.

    JNCI cancer spectrum

    Authors: Jonas Saal, Tobias Bald, Markus Eckstein, Manuel Ritter, Peter Brossart, Jörg Ellinger, Michael Hölzel, Niklas Klümper

  • Reply to Jon Griffin. TIME for a Change? Multimarker Assessment of the Tumour Immune Microenvironment and Metastatic Site Biopsy to Improve Immunotherapy Response Prediction in Muscle-invasive Bladder Cancer. Eur Urol. 2023;43:143-4.

    European urology

    Authors: Niklas Klümper, Michael Hölzel, Markus Eckstein

  • Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors.

    Med (New York, N.Y.)

    Authors: Nicolas Gonzalo Nuñez, Fiamma Berner, Ekaterina Friebel, Susanne Unger, Nina Wyss, Julia Martinez Gomez, Mette-Triin Purde, Rebekka Niederer, Maximilian Porsch, Christa Lichtensteiger, Rafaela Kramer, Michael Erdmann, Christina Schmitt, Lucie Heinzerling, Marie-Therese Abdou, Julia Karbach, Dirk Schadendorf, Lisa Zimmer, Selma Ugurel, Niklas Klümper, Michael Hölzel, Laura Power, Stefanie Kreutmair, Mariaelena Capone, Gabriele Madonna, Lacin Cevhertas, Anja Heider, Teresa Amaral, Omar Hasan Ali, David Bomze, Florentia Dimitriou, Stefan Diem, Paolo Antonio Ascierto, Reinhard Dummer, Elke Jäger, Christoph Driessen, Mitchell Paul Levesque, Willem van de Veen, Markus Joerger, Martin Früh, Burkhard Becher, Lukas Flatz

  • Five-Fraction Stereotactic Radiotherapy for Brain Metastases-A Retrospective Analysis.

    Current oncology (Toronto, Ont.)

    Authors: Julian P Layer, Katharina Layer, Gustavo R Sarria, Fred Röhner, Cas S Dejonckheere, Lea L Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Mümtaz Köksal, Frederic Carsten Schmeel, Niklas Schäfer, Jennifer Landsberg, Michael Hölzel, Ulrich Herrlinger, Matthias Schneider, Frank A Giordano, Leonard Christopher Schmeel

  • CDCP1 expression is frequently increased in aggressive urothelial carcinoma and promotes urothelial tumor progression.

    Scientific reports

    Authors: Miriam Saponaro, Sina Flottmann, Markus Eckstein, Oliver Hommerding, Niklas Klümper, Dillon Corvino, Sana Hosni, Anja Schmidt, Nicolas Mönig, Doris Schmidt, Jörg Ellinger, Marieta Toma, Glen Kristiansen, Tobias Bald, Andrea Alimonti, Manuel Ritter, Michael Hölzel, Abdullah Alajati

  • Single-cell RNA sequencing identifies a population of human liver-type ILC1s.

    Cell reports

    Authors: Benjamin Krämer, Ansel P Nalin, Feiyang Ma, Sarah Eickhoff, Philipp Lutz, Sonia Leonardelli, Felix Goeser, Claudia Finnemann, Gudrun Hack, Jan Raabe, Michael ToVinh, Sarah Ahmad, Christoph Hoffmeister, Kim M Kaiser, Steffen Manekeller, Vittorio Branchi, Tobias Bald, Michael Hölzel, Robert Hüneburg, Hans Dieter Nischalke, Alexander Semaan, Bettina Langhans, Dominik J Kaczmarek, Brooke Benner, Matthew R Lordo, Jesse Kowalski, Adam Gerhardt, Jörg Timm, Marieta Toma, Raphael Mohr, Andreas Türler, Arthur Charpentier, Tobias van Bremen, Georg Feldmann, Arne Sattler, Katja Kotsch, Ali T Abdallah, Christian P Strassburg, Ulrich Spengler, William E Carson, Bethany L Mundy-Bosse, Matteo Pellegrini, Timothy E O'Sullivan, Aharon G Freud, Jacob Nattermann

  • Spatial Immunephenotypes of Distant Metastases but not Matched Primary Urothelial Carcinomas Predict Response to Immune Checkpoint Inhibition.

    European urology

    Authors: Franziska Erlmeier, Niklas Klümper, Laura Landgraf, Pamela L Strissel, Reiner Strick, Danijel Sikic, Helge Taubert, Sven Wach, Carol I Geppert, Veronika Bahlinger, Johannes Breyer, Manuel Ritter, Christian Bolenz, Florian Roghmann, Philipp Erben, Kristina Schwamborn, Ralph M Wirtz, Thomas Horn, Bernd Wullich, Michael Hölzel, Arndt Hartmann, Jürgen E Gschwend, Wilko Weichert, Markus Eckstein

  • Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.

    Science immunology

    Authors: Fiamma Berner, David Bomze, Christa Lichtensteiger, Vincent Walter, Rebekka Niederer, Omar Hasan Ali, Nina Wyss, Jens Bauer, Lena Katharina Freudenmann, Ana Marcu, Eva-Maria Wolfschmitt, Sebastian Haen, Thorben Gross, Marie-Therese Abdou, Stefan Diem, Stella Knöpfli, Tobias Sinnberg, Kathrin Hofmeister, Hung-Wei Cheng, Marieta Toma, Niklas Klümper, Mette-Triin Purde, Oltin Tiberiu Pop, Ann-Kristin Jochum, Steve Pascolo, Markus Joerger, Martin Früh, Wolfram Jochum, Hans-Georg Rammensee, Heinz Läubli, Michael Hölzel, Jacques Neefjes, Juliane Walz, Lukas Flatz