Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19.
Cell reports. Medicine
Authors:
Amit Frishberg, Emma Kooistra, Melanie Nuesch-Germano, Tal Pecht, Neta Milman, Nico Reusch, Stefanie Warnat-Herresthal, Niklas Bruse, Kristian Händler, Heidi Theis, Michael Kraut, Esther van Rijssen, Bram van Cranenbroek, Hans Jpm Koenen, Hidde Heesakkers, Mark van den Boogaard, Marieke Zegers, Peter Pickkers, Matthias Becker, Anna C Aschenbrenner, Thomas Ulas, Fabian J Theis, Shai S Shen-Orr, Joachim L Schultze, Matthijs Kox
SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.
Molecular metabolism
Authors:
Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.
Nature neuroscience
Authors:
Phan Q Duy, Stefan C Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J Kundishora, Sunil Koundal, Maysam Z Pedram, Lucia A Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M M Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M Robert, Amrita K Singh, Garrett Allington, Charuta G Furey, Andrew T Timberlake, Benjamin C Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E Butler, Bob S Carter, Evelyn M R Lake, R Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S Malvankar, Juvianee I Estrada-Veras, Christopher A Walsh, Seth L Alper, Joachim L Schultze, Katrin Paeschke, Angelika Doetzlhofer, F Gregory Wulczyn, Sheng Chih Jin, Richard P Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T Kahle
CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants.
EMBO reports
Authors:
Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gómez Martín, Fabio Bertan, Chester J J Wrobel, Frank C Schroeder, Dan Ehninger, Kristian Händler, Joachim L Schultze, Lukas Schreiber, Gerhild van Echten-Deckert, Pierluigi Nicotera, Daniele Bano
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
Nature communications
Authors:
Gizem Günes Günsel, Thomas M Conlon, Aicha Jeridi, Rinho Kim, Zeynep Ertüz, Niklas J Lang, Meshal Ansari, Mariia Novikova, Dongsheng Jiang, Maximilian Strunz, Mariia Gaianova, Christine Hollauer, Christina Gabriel, Ilias Angelidis, Sebastian Doll, Jeanine C Pestoni, Stephanie L Edelmann, Marlene Sophia Kohlhepp, Adrien Guillot, Kevin Bassler, Hannelore P Van Eeckhoutte, Özgecan Kayalar, Nur Konyalilar, Tamara Kanashova, Sophie Rodius, Carolina Ballester-López, Carlos M Genes Robles, Natalia Smirnova, Markus Rehberg, Charu Agarwal, Ioanna Krikki, Benoit Piavaux, Stijn E Verleden, Bart Vanaudenaerde, Melanie Königshoff, Gunnar Dittmar, Ken R Bracke, Joachim L Schultze, Henrik Watz, Oliver Eickelberg, Tobias Stoeger, Gerald Burgstaller, Frank Tacke, Vigo Heissmeyer, Yuval Rinkevich, Hasan Bayram, Herbert B Schiller, Marcus Conrad, Robert Schneider, Ali Önder Yildirim
Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States.
Cells
Authors:
Lena F Schimke, Alexandre H C Marques, Gabriela Crispim Baiocchi, Caroline Aliane de Souza Prado, Dennyson Leandro M Fonseca, Paula Paccielli Freire, Desirée Rodrigues Plaça, Igor Salerno Filgueiras, Ranieri Coelho Salgado, Gabriel Jansen-Marques, Antonio Edson Rocha Oliveira, Jean Pierre Schatzmann Peron, Gustavo Cabral-Miranda, José Alexandre Marzagão Barbuto, Niels Olsen Saraiva Camara, Vera Lúcia Garcia Calich, Hans D Ochs, Antonio Condino-Neto, Katherine A Overmyer, Joshua J Coon, Joseph Balnis, Ariel Jaitovich, Jonas Schulte-Schrepping, Thomas Ulas, Joachim L Schultze, Helder I Nakaya, Igor Jurisica, Otávio Cabral-Marques
Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors.
Journal of thrombosis and haemostasis : JTH
Authors:
Godfrey S Temba, Nadira Vadaq, Jun Wan, Vesla Kullaya, Dana Huskens, Tal Pecht, Martin Jaeger, Collins K Boahen, Vasiliki Matzaraki, Wieteke Broeders, Leo A B Joosten, Sultana M H Faradz, Gibson Kibiki, Saskia Middeldorp, Duccio Cavalieri, Paolo Lionetti, Philip G de Groot, Joachim L Schultze, Mihai G Netea, Vinod Kumar, Bas de Laat, Blandina T Mmbaga, Andre J van der Ven, Mark Roest, Quirijn de Mast
Reply to: 'Lack of evidence for intergenerational inheritance of immune resistance to infections'.
Nature immunology
Authors:
Natalie Katzmarski, Jorge Domínguez-Andrés, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Händler, Heidi Theis, Marc Beyer, Jos W M van der Meer, Leo A B Joosten, Jörn Walter, Joachim L Schultze, Thierry Roger, Evangelos J Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G Netea