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featured publications

  • Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.

    The EMBO journal

    Authors: Markus P Kummer, Christina Ising, Christiane Kummer, Heela Sarlus, Angelika Griep, Ana Vieira-Saecker, Stephanie Schwartz, Annett Halle, Matthias Brückner, Kristian Händler, Joachim L Schultze, Marc Beyer, Eicke Latz, Michael T Heneka

  • Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis.

    Circulation research

    Authors: Anette Christ, Eicke Latz

  • The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis.

    Trends in molecular medicine

    Authors: Sanne G S Verberk, Kirsten L Kuiper, Mario A Lauterbach, Eicke Latz, Jan Van den Bossche

  • The inflammasome: from bench to bedside.

    Nature reviews. Immunology

    Authors: Eicke Latz

  • BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.

    The Journal of experimental medicine

    Authors: Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L Greve, Markus W Löffler, Olaf-Oliver Wolz, Nadine A Schilling, Jasmin B Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N R Weber

  • Top publication

    Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.

    Cell

    Authors: Hannah Scheiblich, Cira Dansokho, Dilek Mercan, Susanne V Schmidt, Luc Bousset, Lena Wischhof, Frederik Eikens, Alexandru Odainic, Jasper Spitzer, Angelika Griep, Stephanie Schwartz, Daniele Bano, Eicke Latz, Ronald Melki, Michael T Heneka

  • Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.

    Cell reports

    Authors: Shanya Jiang, Nicole M Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A Mandell, Stephen D Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P Weick, Gary A Rosenberg, Eicke Latz, Michael T Heneka, Kiran Bhaskar

  • Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies.

    Journal of immunology (Baltimore, Md. : 1950)

    Authors: Hannah Scheiblich, Luc Bousset, Stephanie Schwartz, Angelika Griep, Eicke Latz, Ronald Melki, Michael T Heneka

  • IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.

    Hypertension (Dallas, Tex. : 1979)

    Authors: Jordyn M Thomas, Yeong H Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M Ferens, Henry Diep, Shalini M Krishnan, Barbara K Kemp-Harper, Paul M O'Connor, Eicke Latz, Thiruma V Arumugam, Tomasz J Guzik, Michael J Hickey, Ashley Mansell, Christopher G Sobey, Antony Vinh, Grant R Drummond

  • Top publication

    Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Immunity

    Authors: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann