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featured publications

  • Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis.

    EBioMedicine

    Authors: Nathalie Niyonzima, Siril S Bakke, Ida Gregersen, Sverre Holm, Øystein Sandanger, Hilde L Orrem, Bjørnar Sporsheim, Liv Ryan, Xiang Yi Kong, Tuva Børresdatter Dahl, Mona Skjelland, Kirsten Krohg Sørensen, Anne Mari Rokstad, Arne Yndestad, Eicke Latz, Lars Gullestad, Geir Ø Andersen, Jan Kristian Damås, Pål Aukrust, Tom E Mollnes, Bente Halvorsen, Terje Espevik

  • 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.

    Autophagy

    Authors: Mario A Lauterbach, Victor Saavedra, Matthew S J Mangan, Anke Penno, Christoph Thiele, Eicke Latz, Lars Kuerschner

  • Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Mice.

    Metabolites

    Authors: Mario A Lauterbach, Eicke Latz, Anette Christ

  • STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression.

    Nature communications

    Authors: Jesse J Balic, Hassan Albargy, Kevin Luu, Francis J Kirby, W Samantha N Jayasekara, Finbar Mansell, Daniel J Garama, Dominic De Nardo, Nikola Baschuk, Cynthia Louis, Fiachra Humphries, Katherine Fitzgerald, Eicke Latz, Daniel J Gough, Ashley Mansell

  • Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.

    FEBS letters

    Authors: Michael Marleaux, Kanchan Anand, Eicke Latz, Matthias Geyer

  • The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles.

    Journal of extracellular vesicles

    Authors: Andreas Zietzer, Mohammed Rabiul Hosen, Han Wang, Philip Roger Goody, Marc Sylvester, Eicke Latz, Georg Nickenig, Nikos Werner, Felix Jansen

  • Jack of all trades inhibits inflammation (in sober people).

    Nature immunology

    Authors: Florian I Schmidt, Eicke Latz

  • Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection.

    Nature microbiology

    Authors: Joel Selkrig, Nan Li, Annika Hausmann, Matthew S J Mangan, Matylda Zietek, André Mateus, Jacob Bobonis, Anna Sueki, Haruna Imamura, Bachir El Debs, Gianluca Sigismondo, Bogdan I Florea, Herman S Overkleeft, Nataša Kopitar-Jerala, Boris Turk, Pedro Beltrao, Mikhail M Savitski, Eicke Latz, Wolf-Dietrich Hardt, Jeroen Krijgsveld, Athanasios Typas

  • Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent.

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    Authors: Marianna M S Beyer, Niklas Lonnemann, Anita Remus, Eicke Latz, Michael T Heneka, Martin Korte

  • Immediate and long-term consequences of COVID-19 infections for the development of neurological disease.

    Alzheimer's research & therapy

    Authors: Michael T Heneka, Douglas Golenbock, Eicke Latz, Dave Morgan, Robert Brown