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Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis.

Frontiers in oncology

Authors: Motaz Hamed, Niklas Schäfer, Christian Bode, Valeri Borger, Anna-Laura Potthoff, Lars Eichhorn, Frank A Giordano, Erdem Güresir, Muriel Heimann, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Elisa Scharnböck, Christina Schaub, Katjana S Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss, Matthias Schneider

OBJECT: Intra-tumoral hemorrhage is considered an imaging characteristic of advanced cancer disease. However, data on the influence of intra-tumoral hemorrhage in patients with brain metastases (BM) remains scarce. We aimed at investigating patients with BM who underwent neurosurgical resection of the metastatic lesion for a potential impact of preoperative hemorrhagic transformation on overall survival (OS).

METHODS: Between 2013 and 2018, 357 patients with BM were surgically treated at the authors' neuro-oncological center. Preoperative magnetic resonance imaging (MRI) examinations were assessed for the occurrence of malignant hemorrhagic transformation.

RESULTS: 122 of 375 patients (34%) with BM revealed preoperative intra-tumoral hemorrhage. Patients with hemorrhagic transformed BM exhibited a median OS of 5 months compared to 12 months for patients without intra-tumoral hemorrhage. Multivariate analysis revealed preoperative hemorrhagic transformation as an independent and significant predictor for worsened OS.

CONCLUSIONS: The present study identifies preoperative intra-tumoral hemorrhage as an indicator variable for poor prognosis in patients with BM undergoing neurosurgical treatment.

Copyright © 2021 Hamed, Schäfer, Bode, Borger, Potthoff, Eichhorn, Giordano, Güresir, Heimann, Ko, Landsberg, Lehmann, Radbruch, Scharnböck, Schaub, Schwab, Weller, Herrlinger, Vatter, Schuss and Schneider.

PMID: 34595109

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