The DEAH helicase and its role in G-quadruplex-dependent processes.

is a member of the DExD/H box helicase family, which comprises a large number of proteins involved in various cellular functions. Recently, the function of in the regulation of G-quadruplexes (G4s) was demonstrated. G4s are alternative nucleic acid structures, which influence many cellular pathways on a transcriptional and post-transcriptional level. In this review we provide an overview of the current knowledge about structure, substrate specificity, and mechanism of action based on the available models and crystal structures. Moreover, we outline its multiple functions in cellular homeostasis, immunity, and disease. Finally, we discuss the open questions and provide potential directions for future research.

© 2020 Walter de Gruyter GmbH, Berlin/Boston.

PMID: 33021960