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Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Cell metabolism

Authors: Siroon Bekkering, Lotte C A Stiekema, Sophie Bernelot Moens, Simone L Verweij, Boris Novakovic, Koen Prange, Miranda Versloot, Jeanine E Roeters van Lennep, Henk Stunnenberg, Menno de Winther, Erik S G Stroes, Leo A B Joosten, Mihai G Netea, Niels P Riksen

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

Copyright © 2019 Elsevier Inc. All rights reserved.

PMID: 31204280

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