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Publications

featured publications

  • Neuroinflammation and immunometabolism in neurodegenerative diseases.

    Current opinion in neurology

    Authors: Neha Lonkar, Eicke Latz, Róisín M McManus

  • NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression.

    Immunity

    Authors: Róisín M McManus, Max P Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Ramón Perea, Johannes C M Schlachetzki, David S Bouvier, Michelle-Amirah Khalil, Mario A Lauterbach, Lea Heinemann, Titus Schlüter, Mehran Shaban Pour, Marta Lovotti, Rainer Stahl, Fraser Duthie, Juan F Rodríguez-Alcázar, Susanne V Schmidt, Jasper Spitzer, Peri Noori, Alberto Maillo, Andreas Boettcher, Brian Herron, John McConville, David Gomez-Cabrero, Jesper Tegnér, Christopher K Glass, Karsten Hiller, Eicke Latz, Michael T Heneka

  • RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells.

    The Journal of experimental medicine

    Authors: Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta, Yun Zhang, Tatjana Reuter, Yuko Ishida, Toshikazu Kondo, Tomoki Chiba, Hiroshi Asahara, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Tsuneyasu Kaisho, Yoichi Furukawa, Eicke Latz, Kohta Nakatani, Yoshihiro Izumi, Yunzhong Nie, Hideki Taniguchi, Kensuke Miyake

  • Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway.

    Cell reports

    Authors: Alexandra Ehrens, Benjamin Lenz, Celia Nieto-Pérez, Eicke Latz, Florian I Schmidt, Achim Hoerauf, Marc P Hübner

  • Systematic assessment of COVID-19 host genetics using whole genome sequencing data.

    PLoS pathogens

    Authors: Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, T Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V Schmidt, Philipp Schommers, Christoph D Spinner, Maria J G T Vehreschild, Thirumalaisamy P Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J Brent Richards, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L Schultze, Peter Nürnberg, Markus M Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C Schulte, Kerstin U Ludwig

  • NIS-Seq enables cell-type-agnostic optical perturbation screening.

    Nature biotechnology

    Authors: Caroline I Fandrey, Marius Jentzsch, Peter Konopka, Alexander Hoch, Katja Blumenstock, Afraa Zackria, Salie Maasewerd, Marta Lovotti, Dorothee J Lapp, Florian N Gohr, Piotr Suwara, Jędrzej Świeżewski, Lukas Rossnagel, Fabienne Gobs, Maia Cristodaro, Lina Muhandes, Rayk Behrendt, Martin C Lam, Klaus J Walgenbach, Tobias Bald, Florian I Schmidt, Eicke Latz, Jonathan L Schmid-Burgk

  • ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.

    Cell reports

    Authors: Ole Kristian Greiner-Tollersrud, Máté Krausz, Vincent Boehler, Aikaterini Polyzou, Maximilian Seidl, Ambra Spahiu, Zeinab Abdullah, Katarzyna Andryka-Cegielski, Felix Immunuel Dominick, Katrin Huebscher, Andreas Goschin, Cristian R Smulski, Eirini Trompouki, Regina Link, Hilmar Ebersbach, Honnappa Srinivas, Martine Marchant, Georgios Sogkas, Dieter Staab, Cathrine Vågbø, Danilo Guerini, Sebastian Baasch, Eicke Latz, Gunther Hartmann, Philippe Henneke, Roger Geiger, Xiao P Peng, Bodo Grimbacher, Eva Bartok, Ingrun Alseth, Max Warncke, Michele Proietti

  • Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3 mice.

    Cell death and differentiation

    Authors: Felix D Weiss, Yubell Alvarez, Farhad Shakeri, Anshupa Sahu, Petro Leka, Alesja Dernst, Jessika Rollheiser, Matilde Vasconcelos, Adriana Geraci, Fraser Duthie, Rainer Stahl, Hye Eun Lee, Anne-Kathrin Gellner, Andreas Buness, Eicke Latz, Felix Meissner

  • Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation.

    Cell reports

    Authors: Wei Wang, Alesja Dernst, Bianca Martin, Lucia Lorenzi, Maria Cadefau-Fabregat, Kshiti Phulphagar, Antonia Wagener, Christina Budden, Neil Stair, Theresa Wagner, Harald Färber, Andreas Jaensch, Rainer Stahl, Fraser Duthie, Susanne V Schmidt, Rebecca C Coll, Felix Meissner, Sergi Cuartero, Eicke Latz, Matthew S J Mangan

  • Prospective Cytokine Profiling in Aqueous Humor Reveals a Proinflammatory Microenvironment in Highly Dense Nuclear Cataracts.

    Investigative ophthalmology & visual science

    Authors: Catharina Latz, Annika Licht, Alireza Mirshahi, Eicke Latz, Kai Zimmer