Skip to main content

Publications

featured publications

  • Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.

    Nature communications

    Authors: Lisa D J Schiffelers, Yonas M Tesfamariam, Lea-Marie Jenster, Stefan Diehl, Sophie C Binder, Sabine Normann, Jonathan Mayr, Steffen Pritzl, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L Ploegh, Florian I Schmidt

  • Multi-omics characterization of the monkeypox virus infection.

    Nature communications

    Authors: Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I Schmidt, Michael Way, Roland Rad, Andrew G Bowie, Ulrike Protzer, Andreas Pichlmair

  • Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.

    Nature

    Authors: Chao Wei, Wei Jiang, Ruiyu Wang, Haoyu Zhong, Huabin He, Xinwei Gao, Shilin Zhong, Fengting Yu, Qingchun Guo, Li Zhang, Lisa D J Schiffelers, Bin Zhou, Martin Trepel, Florian I Schmidt, Minmin Luo, Feng Shao

  • Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection.

    Nature communications

    Authors: Jonas D Albarnaz, Joanne Kite, Marisa Oliveira, Hanqi Li, Ying Di, Maria H Christensen, Joao A Paulo, Robin Antrobus, Steven P Gygi, Florian I Schmidt, Edward L Huttlin, Geoffrey L Smith, Michael P Weekes

  • Top publication

    Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.

    Nature communications

    Authors: Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D J Schiffelers, Florian I Schmidt, Matthias Geyer

  • Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis.

    The Journal of experimental medicine

    Authors: Kim Samirah Robinson, Gee Ann Toh, Muhammad Jasrie Firdaus, Khek Chian Tham, Pritisha Rozario, Chrissie K Lim, Ying Xiu Toh, Zhi Heng Lau, Sophie Charlotte Binder, Jacob Mayer, Carine Bonnard, Florian I Schmidt, John E A Common, Franklin L Zhong

  • ASC oligomer favors caspase-1CARD domain recruitment after intracellular potassium efflux.

    The Journal of cell biology

    Authors: Fátima Martín-Sánchez, Vincent Compan, Alejandro Peñín-Franch, Ana Tapia-Abellán, Ana I Gómez, María C Baños-Gregori, Florian I Schmidt, Pablo Pelegrin

  • Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.

    Cell host & microbe

    Authors: Jason P Lynch, Coral González-Prieto, Analise Z Reeves, Sena Bae, Urmila Powale, Neha P Godbole, Jacqueline M Tremblay, Florian I Schmidt, Hidde L Ploegh, Vikram Kansra, Jonathan N Glickman, John M Leong, Charles B Shoemaker, Wendy S Garrett, Cammie F Lesser

  • Top publication

    Mitochondrial damage activates the NLRP10 inflammasome.

    Nature immunology

    Authors: Tomasz Próchnicki, Matilde B Vasconcelos, Kim S Robinson, Matthew S J Mangan, Dennis De Graaf, Kateryna Shkarina, Marta Lovotti, Lena Standke, Romina Kaiser, Rainer Stahl, Fraser G Duthie, Maximilian Rothe, Kateryna Antonova, Lea-Marie Jenster, Zhi Heng Lau, Sarah Rösing, Nora Mirza, Clarissa Gottschild, Dagmar Wachten, Claudia Günther, Thomas A Kufer, Florian I Schmidt, Franklin L Zhong, Eicke Latz

  • Top publication

    Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.

    Science (New York, N.Y.)

    Authors: Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja Vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H Christensen, Yonas M Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E Müller, Manabu Igarashi, Hiroki Kato