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featured publications

  • 2'-O-methyltransferase-deficient yellow fever virus: Restricted replication in the midgut and secondary tissues of Aedes aegypti mosquitoes severely limits dissemination.

    PLoS pathogens

    Authors: Anja Vom Hemdt, Alexandra L Thienel, Katrin Ciupka, Janett Wieseler, Hannah M Proksch, Martin Schlee, Beate M Kümmerer

  • Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture.

    Nature communications

    Authors: Vasiliya Kril, Michael Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud-Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L Thienel, Beate M Kümmerer, Ambroise Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera

  • Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control.

    Cell host & microbe

    Authors: Philipp Schult, Beate Mareike Kümmerer, Markus Hafner, Katrin Paeschke

  • TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest.

    BMC biology

    Authors: Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U Ludwig, Beate M Kümmerer, Katrin Paeschke

  • Top publication

    Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury.

    Journal of hepatology

    Authors: Carl-Philipp Hackstein, Jasper Spitzer, Konstantinos Symeonidis, Helena Horvatic, Tanja Bedke, Babett Steglich, Sabine Klein, Lisa M Assmus, Alexandru Odainic, Jennifer Szlapa, Nina Kessler, Marc Beyer, Ricarda Schmithausen, Eicke Latz, Richard A Flavell, Natalio Garbi, Christian Kurts, Beate M Kümmerer, Jonel Trebicka, Axel Roers, Samuel Huber, Susanne V Schmidt, Percy A Knolle, Zeinab Abdullah

  • Top publication

    Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.

    Science (New York, N.Y.)

    Authors: Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja Vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H Christensen, Yonas M Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E Müller, Manabu Igarashi, Hiroki Kato

  • Top publication

    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.

    The Journal of experimental medicine

    Authors: Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D Wuerth, Lisa D J Schiffelers, Yonas M Tesfamariam, Florian N Gohr, Laura Klein, Ines H Kaltheuner, Stefan Ebner, Dorothee J Lapp, Jacob Mayer, Jonas Moecking, Hidde L Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M Kümmerer, Florian I Schmidt

  • Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases.

    The EMBO journal

    Authors: Valter Bergant, Shintaro Yamada, Vincent Grass, Yuta Tsukamoto, Teresa Lavacca, Karsten Krey, Maria-Teresa Mühlhofer, Sabine Wittmann, Armin Ensser, Alexandra Herrmann, Anja Vom Hemdt, Yuriko Tomita, Shutoku Matsuyama, Takatsugu Hirokawa, Yiqi Huang, Antonio Piras, Constanze A Jakwerth, Madlen Oelsner, Susanne Thieme, Alexander Graf, Stefan Krebs, Helmut Blum, Beate M Kümmerer, Alexey Stukalov, Carsten B Schmidt-Weber, Manabu Igarashi, Thomas Gramberg, Andreas Pichlmair, Hiroki Kato

  • RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection.

    Molecular therapy. Nucleic acids

    Authors: Samira Marx, Beate M Kümmerer, Christian Grützner, Hiroki Kato, Martin Schlee, Marcel Renn, Eva Bartok, Gunther Hartmann

  • Top publication

    Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.

    Immunity

    Authors: Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J Rieke, Jenny Bischoff, Malte B Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Händler, Gary Reynolds, Nils Blüthgen, Gudrun Hack, Claudia Finnemann, Hans D Nischalke, Christian P Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne V Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J Ball, Joe M Johnson, Paul-Albert Koenig, Florian I Schmidt, Muzlifah Haniffa, James R Heath, Beate M Kümmerer, Verena Keitel, Björn Jensen, Paula Stubbemann, Florian Kurth, Leif E Sander, Birgit Sawitzki, Anna C Aschenbrenner, Joachim L Schultze, Jacob Nattermann